General Information

  • ID:  hor004398
  • Uniprot ID:  P08611
  • Protein name:  Kassinin
  • Gene name:  NA
  • Organism:  Kassina senegalensis (Senegal running frog)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Kassina (genus), Hyperoliidae (family), Microhyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DVPKSDQFVGLM
  • Length:  12
  • Propeptide:  DVPKSDQFVGLM
  • Signal peptide:  NA
  • Modification:  T12 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  1myu(PDB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    1myu.pdbhor004398_AF2.pdbhor004398_ESM.pdb

Physical Information

Mass: 153193 Formula: C59H94N14O19S
Absent amino acids: ACEHINRTWY Common amino acids: DV
pI: 4.11 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: -2.5 Boman Index: -1266
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 80.83
Instability Index: 1185.83 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  891753
  • Title:  Amino Acid Composition and Sequence of Kassinin, a Tachykinin Dodecapeptide From the Skin of the African Frog Kassina Senegalensis